WD Repeat Containing Domain Protein 61 (WDR61)

WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance.Zhu et al. (2005) purified WDR61 from a 600-kD PAF complex and from a 400-kD SKI complex in HeLa cell nuclear extracts.Zhu et al. (2005) determined that the human PAF and SKI complexes interact. SKI8 RNA interference showed that SKI8 was required for PAF-dependent mono- and trimethylation of histone H3 at lys4 (H3-K4) and dimethylation of H3-K79, but not dimethylation of H3-K36.The International Radiation Hybrid Mapping Consortium mapped the WDR61 gene to chromosome 15.