WD Repeat Containing Domain Protein 74 (WDR74)

WDR74 contains 6 WD repeats and has two isoforms. this gene is expressed at high level, 2.6 times the average gene in this release. The gene contains 17 different introns . Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. There are 3 probable alternative promotors, 3 non overlapping alternative last exons and 5 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5""" end, truncation of the 3""" end, presence or absence of 2 cassette exons, overlapping exons with different boundaries, alternative splicing or retention of 6 introns. 656 bp of this gene are antisense to spliced gene tarkarby, raising the possibility of regulated alternate expression. This gene WDR74 maps on chromosome 11, at 11q12.3.