YEATS Domain Containing Protein 2 (YEATS2)

YEATS2 is a scaffolding subunit of the ADA2A (TADA2A)-containing (ATAC) histone acetyltransferase complex. In addition to either GCN5 (KAT2A) or PCAF (KAT2B), which are paralogous acetyltransferases, other YEATS2-associated ATAC subunits included MAP3K7, ADA3 (TADA3), ADA2A, MBIP, WDR5 , STAF36 (CCDC101), NC2-beta (DR1), POLE3, and POLE4. Domain analysis showed that the YEATS domain was not necessary for interaction of YEATS2 with any other ATAC subunits tested. However, deletion of the N terminus plus the YEATS domain abolished or hindered interaction of YEATS2 with all ATAC subunits except NC2-beta. Deletion of the histone-fold domain abolished YEATS2 binding to NC2-beta, MBIP, and WDR5.