Zinc And Ring Finger Protein 3 (ZNRF3)

By sequencing clones obtained from a human brain cDNA library, Hirosawa et al. (1999) cloned ZNRF3, which they designated KIAA1133.The transcript contains a repetitive element in its 3-prime region, and the deduced protein contains 550 amino acids. RT-PCR ELISA detected moderate expression of ZNRF3 in nearly all tissues examined, including adult and fetal brain and all specific adult brain regions. Expression was highest in kidney.Hartz (2008) mapped the ZNRF3 gene to chromosome 22q12.1 based on an alignment of the ZNRF3 sequence with the genomic sequence (build 36.1).The displayed sequence is further processed into a mature form.