Zinc Finger And AT Hook Domain Containing Protein (ZFAT)

ZFAT1 gene consists of 19 exons. The gene undergoes alternative splicing of exons 1, 2, 3, and 9b, with the truncated transcript TRZFAT containing only 10 exons due to a stop codon in exon 9b. The longest ZFAT1 transcript consists of 16 exons. The small antisense transcript SASZFAT is composed of sequences from exons 9a and 9b.The longest predicted protein product consists of 1,243 amino acids with 18 zinc finger repeat domains. RT-PCR expression analysis in human tissues revealed that ZFAT1 is strongly expressed in placenta, kidney, spleen, testis, and peripheral blood lymphocytes. A truncated splice variant (TRZFAT) was strongly expressed in placenta, ovary, and tonsil. The TRZFAT variant encodes an 846-amino acid protein with 11 zinc finger repeat domains.