Zinc Finger And BTB Domain Containing Protein 1 (ZBTB1)

ZBTB1, Contains 1 BTB (POZ) domain, May be involved in transcriptional regulation. The BTB domain is a protein-protein interaction module consisting of approximately 120 amino acids that is found in over 600 different proteins in organisms ranging from yeast to humans. The domain was first identified as a conserved sequence element in the developmentally regulated Drosophila proteins Broad-complex, Tramtrack and Bric-abrac. The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is often found at the N-termini of several zinc finger transcription factors as well as Shaw-type potassium channels. Experimental studies have strongly implicated the BTB domain in the regulation of gene expression through the local control of chromatin conformation.