Zinc Finger And BTB Domain Containing Protein 10 (ZBTB10)

ZBTB10 is a novel zinc finger protein that inhibits Sp1-dependent activation. In this regard, ZBTB10 has been identified as a putative suppressor of Sp proteins such as Sp1, Sp3 and Sp4. Sp proteins belong to the Sp/Kruppel-like factor (KLF) family of transcription factors and are overexpressed in certain cancers.  MiR-27a suppresses ZB1B10 expression and suppression of ZBTB10 by overexpressed miR-27a may be linked to overexpression of Sp proteins in breast cancer cells. Introduction of antisense miR-27a resulted in increased expression of ZBTB10 mRNA and decreased expression of Sp1, Sp3 and Sp4 mRNA and protein.  It is thought that the oncogenic activity of miR-27a may be due, in part, to suppression of ZBTB10 which leads to increased expression of Sp proteins thereby contributing to the proliferative and angiogenic  cancer phenotype.