Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17)

MIZ1 associates with microtubules, can bind directly to the low density lipoprotein receptor (LDLR) promoter, and can activate LDLR transcription. MIZ1 also binds to the promoter and activates transcription of other T113242 (a synthetic drug)-induced genes such as alpha-2 integrin.MIZ1 appears to be regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton.The deduced human MIZ1 protein shares 92% sequence identity with the closely related mouse protein Z13. MIZ1 has a potent growth arrest function; HeLa cells expressing recombinant MIZ1 progress into S phase but not into mitosis. MIZ1 can bind to and transactivate the adenovirus major late and cyclin D1 (CCND1) promoters.