Zinc Finger And BTB Domain Containing Protein 20 (ZBTB20)

The deduced 733-amino acid protein has a molecular mass of 80 kD and contains an N-terminal BTB/POZ domain and a C-terminal zinc finger domain with 4 typical Kruppel-type C2H2 motifs. Within the BTB/POZ domain, ZNF288 shares high homology with BCL6, a POK protein putatively involved in lymphopoiesis. Northern blot analysis detected expression of ZNF288 in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver; no expression was found in bone marrow. Two transcripts of approximately 7.4 kb and 2.8 kb were present in most of the tissues, with the 2.8-kb transcript predominant in spleen, lymph node, and peripheral blood leukocytes. RT-PCR analysis detected expression in dendritic cells, monocytes, B cells, and T cells.