Zinc Finger And BTB Domain Containing Protein 34 (ZBTB34)

By database searching and EST assembly, Qi et al. (2006) identified a member of the BTB/POZ protein family, designated ZBTB34, which had previously been identified as KIAA1993 by Ohara et al. (2002). The deduced ZBTB34 protein contains 504 amino acids with a BTB/POZ domain in the N terminus and 3 C2H2 zinc fingers in the C terminus. Northern blot and RT-PCR analyses demonstrated weak transcription in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, kidney, liver, placenta, and peripheral blood. Immunofluorescence studies localized the protein to the nucleus.Using a Gal4 reporter system, Qi et al. (2006) showed that ZBTB34 could repress transcription by 50 to 80%.Qi et al. (2006) determined that the ZBTB34 gene contains 2 exons.