Zinc Finger And BTB Domain Containing Protein 48 (ZBTB48)

HKR3 was one of several partially characterized zinc finger genes identified by Ruppert et al. (1988) that are related to the GLI protooncogene and which are members of the Kruppel-related gene family. Kruppel-like zinc finger proteins are characterized by a highly conserved sequence of 7 amino acids termed the H/C link (thr-gly-glu-lys-pro-tyr-X) that connect the fingers. HKR3 was mapped by Ruppert et al. (1988) to chromosome 1. The predicted 77-kD protein has 11 C2H2 zinc fingers separated by H/C links. The N terminus of the protein contains a tramtrack-associated box (TAB) domain and an acidic activation domain. Maris et al. (1996) showed that the HKR3 gene contains 11 exons and spans about 9.5 kb of genomic DNA. It is approximately 40 kb from the marker D1S214. A CpG island occurs in the 5-prime region of the gene.