Zinc Finger And SCAN Domain Containing Protein 1 (ZSCAN1)

ZSCAN1 contains 3 C2H2-type zinc fingers, 1 SCAN box domain.The SCAN domain is a highly conserved 84 residue motif that is found near the N-terminus of a subfamily of C2H2 zinc finger proteins. The SCAN domain, which is also known as the leucine rich region (LeR), functions as a protein interaction domain, mediating self-association or selective association with other proteins. Bioinformatic approaches were used to identify 71 SCAN domains in the human genome and to define the structures of the members in the human SCAN domain family. In addition to a single SCAN domain, the members of the family can have a variable number of zinc fingers (2-22), a KRAB domain, as well as a novel N-terminal motif. The genes encoding SCAN domains are clustered, often in tandem arrays, in both the human and mouse genomes and are capable of generating isoforms that may affect the function of family members.