Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT)

ZGPAT, Contains 1 C3H1-type zinc finger. Contains 1 G-patch domain. Transcription repressor that specifically binds the 5"""-GGAG[GA]A[GA]A-3""" consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Six new targets of epigenetic inactivation (IRX3, WNT10A, WNT6, RARalpha, BMP7 and ZGPAT). These targets displayed cell line and tumor specific differential methylation when compared with normal brain samples, suggesting they may have utility as biomarkers.