Zinc Finger, CCHC-Type And RNA Binding Motif 10 (ZCRB10)

ZCCHC10 contains one CCHC-type zinc-finger, suggesting a role in transcriptional regulation. Multiple isoforms of ZCCHC10 exist due to alternative splicing events. The gene encoding ZCCHC10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.