Zinc Finger, DHHC-Type Containing Protein 23 (ZDHHC23)

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC23 (zinc finger, DHHC domain containing 23),  is a 409 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteineconjugated protein to an S-palmitoyl protein and free CoA. ZDHHC23 may play a role in NOS1 regulation and targets the synaptic membrane. By regulating the enzymatic activity of NOS1, ZDHHC23 may effect different pathological conditions including nerve regeneration, neuron loss or survival and pain processing.