Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26)

RT-PCR detected ZFYVE26 expression in all tissues examined. Highest expression was in ovary, followed by placenta, lung, and kidney. In vitro-translated ZFYVE26 had an apparent molecular mass of more than 100 kD by SDS-PAGE.The 2,539-residue protein has a 9.7-kb mRNA transcript and is expressed in various human tissues, particularly adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. In situ hybridization showed wider and stronger Zfyve26 expression in embryonic rat brain compared to adult rat brain, particularly in the spinal cord and cortical, cerebellar, thalamic, and hippocampal neuroepithelia. In COS-7 cells, ZFYVE26 colocalized partially with markers of endoplasmic reticulum and endosomes.