Zinc Finger, GATA Like Protein 1 (ZGLP1)

GLP1 acts as a transcriptional repressor of GATA6 and that this function requires the 2 GLP1 zinc fingers. knockout Glp1 mice were viable with no detectable organ defects but were infertile. Loss of Glp1 resulted in defective sperm development and a marked reduction in mature spermatids. In females, loss of Glp1 led to a severe block in germ cell development that was observed as early as embryonic day 17.5.GLP1 is a critical nuclear repressor in somatic cells of the gonad that is required for germ cell development.The deduced 271-amino acid human and 266-amino acid mouse GLP1 proteins have 2 highly conserved zinc finger regions. Northern blot analysis and in situ hybridization demonstrated restricted expression of mouse Glp1 in somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries.