Zinc Finger, MYND-Type Containing Protein 11 (ZMYND11)

ZMYND11 was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.The deduced 562-amino acid protein had an apparent molecular mass of about 69 kD following in vitro transcription and translation. BS69 contains 2 N-terminal zinc finger motifs, followed by a nuclear localization signal and a C-terminal E1A-binding domain. Northern blot analysis detected a 4.7-kb transcript in all mouse tissues examined, with highest expression in kidney.The deduced BRAM1 protein contains the C-terminal 186 amino acids of BS69 preceded by 12 amino acids unique to BRAM1.