Zinc Finger, Matrin Type Protein 1 (ZMAT1)

ZMAT1 encodes a zinc finger protein. Alternatively spliced transcript variants have been described. Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Zinc finger matrin-type protein 1 (ZMAT1) is a 638 amino acid protein that contains three matrin-type zinc fingers. The matrin-type zinc finger, which is very similar in structure to the classical DNA-binding C2H2 zinc finger, was first identified in the protein matrin-3. It has also been identified in several spliceosome RNA-binding proteins, suggesting a role in pre-mRNA binding. ZMAT1 is localized to the nucleus, and alternative splicing events produce two isoforms of this protein.