Zinc Finger Protein 10 (ZNF10)

Zinc finger protein 10 is a protein contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.The deduced 462-amino acid protein has a calculated molecular mass of at least 50 kD. It has 11 consecutive zinc fingers containing conserved cys/his residues, with variations in fingers 1 and 11. Northern blot analysis showed variable KOX1 expression in several human cell lines, with highest expression in the U937 myelomonocytic cell line. Several KOX1 transcripts were detected, suggesting it may be alternatively spliced.