Zinc Finger Protein 107 (ZNF107)

The deduced 783-amino acid protein has a calculated molecular mass of 90.67 kD and contains 25 C2H2-type zinc fingers. ZNF107 shares 70% homology with both ZNF91 and ZNF117. The 5-prime untranslated region contains a KRAB domain. Northern blot analysis detected a 6.2-kb transcript in human brain, heart, skeletal muscle, kidney, and pancreas. RT-PCR analysis detected expression in human aorta, liver, lung, and cultured umbilical vein endothelial cells, umbilical artery smooth muscle cells, and HepG2 cells.ZNF107 expression in cultured human umbilical vein endothelial cells decreased in response to a shift from 20% fetal calf serum to serum-free media. ZNF107 may play a role in serum-dependent cellular processes, such as cell proliferation and survival.