Zinc Finger Protein 121 (ZNF121)

The insert of one positive clone of 1,226 nucleotides contained a novel open reading frame, designated ZNF121, with 9 zinc finger motifs; in addition, 10 repeats of the pentanucleotide sequence (ATTTT) were found 223 nucleotides after a stop codon and were followed by an Alu repeat. The pentanucleotide repeat was polymorphic in the CEPH families, with 7 alleles ranging in size from 147 to 197 nucleotides.ZNF121 was mapped to chromosome 19 by use of commercially available mapping panels of hybrid cell lines and was designated D19S204. Using the polymorphism, Chen et al. (1993) showed that it was strongly linked to markers on 19p in an area in which other zinc finger sequences and multiple cosmid clones containing zinc fingers had previously been localized.