Zinc Finger Protein 140 (ZNF140)

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. One abundant class of such transcriptional regulators resembles the Drosophila Kruppel segmentation gene product due to the presence of repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links. The ZNF140 cDNA predicts a 457-amino acid Kruppel-type zinc finger protein containing an N-terminal KRAB domain. ZNF140 protein contains 10 zinc finger domains and both the KRAB A and B boxes. Northern blot analysis detected ZNF140 expression in all tissues examined.Margolin et al. (1994) demonstrated that the KRAB domain of ZNF140 functions as a potent transcriptional repressor domain when fused to the yeast GAL4 DNA-binding domain.