Zinc Finger Protein 141 (ZNF141)

A zinc finger-encoding cDNA, ZNF141, of the C2-H2/KRAB subfamily. ZNF141 was expressed ubiquitously at low levels in all tissues analyzed.ZNF141 maps to the distal end of a 2.2-Mb smallest region of deletion overlap, 300 kb from the 4p telomere, on a cosmid defining the anonymous locus D4S90. By FISH, bright signals were located at 19p12 in addition to 4p16.3; evidence from interphase FISH and FISH to elongated meiotic chromosomes suggested that the signal on 19p12 was due to the presence of a cluster of at least 3 cross-hybridizing loci. FISH studies of a reciprocal t(4;8)-translocation associated with familial occurrence of the Wolf-Hirschhorn syndrome showed that ZNF141 was translocated to the derivative chromosome 8.