Zinc Finger Protein 16 (ZNF16)

Zinc Finger Protein 16(ZNF16) contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified.By isotopic in situ hybridization, Rousseau-Merck et al. (1995) assigned the KOX9 gene to 8q24, where the KOX4 gene had been previously mapped. From pulsed field gel electrophoresis data, they concluded that KOX4 and KOX9 lie within less than 580 kb of each other. They tabulated a total of 18 different KOX genes that are located in pairs within 9 DNA fragments of 200 to 580 kb on 7 different chromosomes.