Zinc Finger Protein 169 (ZNF169)

Using sequence tagged site (STS) mapping and somatic cell hybrid panel analysis to construct YAC contigs spanning the critical region for several disease loci on chromosome 9q22.1-q31, Chidambaram et al. (1997) identified a genomic cosmid containing a novel open reading frame, which they called ZNF169. The deduced ZNF169 protein has a region showing similarity to the A box of Kruppel-like zinc finger proteins, and 13 Kruppel-type zinc finger domains. By Northern blot analysis of human tissue RNAs, Blair et al. (1998) demonstrated that ZNF169 is highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine, and not expressed in adult brain or spinal cord.Levanat et al. (1997) mapped the ZNF169 gene to chromosome 9q22.3, very close to D9S196 and D9S280.