Zinc Finger Protein 174 (ZNF174)

Members of the Cys2-His2 zinc finger class of transcription factors appear to be involved in the transcriptional repression of growth factor gene expression.The predicted ZNF174 protein contains 3 C-terminal tandem zinc fingers, a single potential phosphorylation site, a putative nuclear localization signal, and an N-terminal element termed the SCAN box, which is also found in a number of other zinc finger proteins. The authors demonstrated that recombinant ZNF174 can repress expression driven by the promoters of the PDGFB and TGFB1 genes. Northern blot analysis detected a major 2.5-kb ZNF174 transcript in a wide variety of adult human tissues, with the highest levels found in ovary and testis.