Zinc Finger Protein 184 (ZNF184)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA.By exon trapping using YAC contigs spanning the 6p21.3 region, which contains a cluster of zinc finger protein genes, Goldwurm et al. (1997) isolated a partial cDNA, designated ZNF184, from a placental library. Sequence analysis indicated that ZNF184 is a classic Kruppel zinc finger gene with a conserved C2H2 domain at the C terminus and Kruppel-associated boxes (KRAB) A and B at the N terminus. Northern blot analysis revealed expression of ZNF184 as a 3.2-kb transcript in all tissues analyzed, with predominant expression in testis.