Zinc Finger Protein 20 (ZNF20)

Rousseau-Merck et al. (1993) mapped KOX6 and KOX13 (ZNF20) to 19p13.3-p13.2. They showed by pulsed field gel electrophoresis experiments that the pair of genes lie within a DNA segment less than 200 kb long.A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases.