Zinc Finger Protein 207 (ZNF207)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA.Pahl et al. (1998) isolated a human vascular smooth muscle cell cDNA encoding a protein that they designated ZNF207. The predicted 478-amino acid protein is composed of nearly 20% proline residues and contains a potential nuclear localization signal at the N-terminus and 2 C2H2 zinc finger motifs. Northern blot analysis revealed that ZNF207 is expressed ubiquitously.By fluorescence in situ hybridization, Pahl et al. (1998) mapped the ZNF207 gene to 6p21.3. Rasooly (1999) noted that the ZNF207 sequence is contained within a cloned region from chromosome 17.