Zinc Finger Protein 208 (ZNF208)

Using probes derived from a ZNF91 cDNA to screen a pool of human chromosome 19-specific cosmids that had hybridized to a degenerate oligonucleotide corresponding to the H/C link region, Bellefroid et al. (1993) isolated the genes of several distinct ZNF91 subfamily members, including ZNF208, which they called ZNF95. They found that ZNF91-related genes were widely expressed in human tissues, with highest expression in T-lymphoid cells.The full-length transcript predicts a 1,317-amino acid protein consisting of 2 KRAB protein-interacting domains and 41 ZNF (28-amino acid) repeats. A splice variant, resulting from the use of an alternative polyadenylation signal, predicts a 77-amino acid peptide consisting only of the KRAB protein-interacting domains. Northern blot analysis revealed expression of both transcripts in all tissues examined.