Zinc Finger Protein 212 (ZNF212)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.Becker et al. (1997) reported the cloning of a C2H2-type, or Kruppel-related, zinc finger protein from a human hippocampus cDNA library. The partial cDNA, designated ZNF212, encodes a predicted 356-amino acid protein, with 4 C-terminal C2H2 zinc finger motifs and an N-terminal Kruppel-associated box (KRAB).