Zinc Finger Protein 213 (ZNF213)

C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.By sequencing candidate genes within the FMF locus on chromosome 16, PCR of fetal brain, fetal liver, and lymph node cDNA libraries, and screening a peripheral blood leukocyte cDNA library, Chen et al. (1999) cloned ZNF213. The deduced 424-amino acid protein contains an N-terminal leucine-rich domain, followed by a Kruppel-associated box and C-terminal zinc fingers. Northern blot analysis detected a 3.8-kb transcript in all tissues examined. Highest expression was detected in testis, followed by ovary, small intestine, prostate, spleen, thymus, mucosal lining of colon, and peripheral blood lymphocytes.ZNF213 gene contains 7 exons and spans about 8.0 kb. The 5-prime untranslated region is GC rich.