Zinc Finger Protein 230 (ZNF230)

The cDNA of znf230 contains a 690 nt open reading frame (ORF), with the start codon ATG at position 125 and stop codon TGA at position 815, encoding a polypeptide of 230 aa. A canonical polyadenylation signal AATAAA is found 18bp upstream of the poly (A) tail. A ring finger domain of C3HC4 type was found at the C-terminus (from aa residue 155 to 191). By comparing its nt and aa sequences with those of human homolog, 92% and 98% identity was observed respectively. Aligned aa sequence of ring finger domain of znf230 with those of other species indicates that this domain is highly conserved. After searching the human-mouse homology map, the mouse znf230 was mapped on chromosome 7. This result was also confirmed by chromosomal localization of its genomic sequence. Mouse znf230 gene spans at least 28 kb genomic sequences and the cDNA is split into six exons.