Zinc Finger Protein 25 (ZNF25)

Zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases.By a combination of in situ chromosomal hybridization and somatic cell hybrid analysis, Rousseau-Merck et al. (1992) concluded that the ZNF25 gene is located on 10q, centromeric to a breakpoint in band 10q11.2, in the region 10p11.2-q11.2.