Zinc Finger Protein 26 (ZNF26)

Zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases.Seite et al. (1991) mapped a member of the human zinc finger Kruppel family, ZNF26 (KOX20), to 12q24.33 by a combination of mouse-human somatic cell hybrids and in situ hybridization. Huebner et al. (1991) mapped KOX20 to 12q13-qter where KOX1 (194538) also maps.