Zinc Finger Protein 264 (ZNF264)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. By screening human brain cDNAs for the potential to encode proteins that are at least 50 kD, Ishikawa et al. (1997) isolated a ZNF264 cDNA, which they called KIAA0412. The deduced 627-amino acid full-length ZNF264 protein shares 54.3% amino acid sequence identity with the Kruppel-related zinc finger protein ZNF184 across 385 residues. By SDS-PAGE, in vitro transcribed/translated ZNF264 had an apparent molecular mass of approximately 84 kD. RT-PCR detected ZNF264 expression in all human tissues tested, with relatively high expression in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.