Zinc Finger Protein 266 (ZNF266)

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. By screening a human monoblast cell line (U-937) cDNA library with a degenerate oligonucleotide based on a conserved region of Kruppel-related zinc finger proteins that encompasses the H/C link, Abrink et al. (1995) isolated cDNAs encoding 42 distinct Kruppel-related zinc finger proteins, including ZNF266, which they called HZF1. The partial ZNF266 cDNA, which lacks 5-prime coding sequence, encodes 7 C-terminal zinc finger domains. Northern blot analysis detected a major 4.5-kb ZNF266 transcript in HeLa cells, U-937 cells, and PMA-induced U-937 cells, with higher expression in the monocyte/macrophage lineages.