Zinc Finger Protein 280D (ZNF280D)

The ZNF280D protein is 979 amino acids in length. The protein contains a domain of unknown function spanning from amino acid 45 to amino acid 230. DUF4195 is a family that is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains; the function is unknown. ZNF280D protein also contains five highly conserved Cys2His2-type zinc finger domains. Zinc fingers have the ability to bind DNA, which supports the speculative role of ZNF280D as a transcription factor. The protein has a weight of approximately 109.3 kdal. Charge cluster analysis reveals a negative charge cluster near the N-terminus from amino acids 16-43. Charge clusters are associated with functional domains of cellular transcription factors, providing further support for ZNF280D as a possible transcription factor.