Zinc Finger Protein 282 (ZNF282)

Human T-cell leukemia virus type I (HTLV-1) gene expression is negatively regulated by the U5 repressive element (U5RE) of its long terminal repeat (LTR). The deduced 671-amino acid HUB1 protein has 5 C-terminal zinc finger domains which show significant homology to the zinc fingers of the Drosophila repressor protein Kruppel, and a Kruppel-associated box (KRAB)-like domain. Northern blot analysis of human tissue RNAs detected a ubiquitously expressed 4.0-kb transcript. The authors determined that HUB1 is a transcriptional repressor that binds to the U5RE. They found that the KRAB-like domain of HUB1 exerts an activation, not repressive effect, and identified a new repressive domain, named HUB1 repressive (HUR) domain, near the N terminus of the protein.