Zinc Finger Protein 3 (ZNF3)

Using a consensus sequence of a mouse zinc finger motif as probe, Pannuti et al. (1988) obtained a partial clone of ZNF3, which they called cHF.12, from a placenta cDNA library. ZNF3 has at least 6 finger repeats. Northern blot analysis of mRNA from cell lines of various tissue origin showed ubiquitous expression of a 3.5-kb transcript. Expression of ZNF3 was drastically reduced upon terminal differentiation of 2 human myeloid cell lines.Using a cDNA probe isolated from a human liver cDNA library by means of a mouse DNA segment containing multiple copies of a 7-amino acid zinc finger domain, for the study of human-hamster cell hybrids, Archidiacono et al. (1989) showed that one sequence identified by probe A8-51 is located on chromosome 5.