Zinc Finger Protein 30 Homolog (ZFP30)

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7. Zfp30 cDNA probes were used to identify restriction fragment length polymorphisms between C57BL/6J and DBA/2J DNAs. A size variant was identified with KpnI and used to type the BXD recombinant inbred strains (data not shown). The strain distribution pattern was found to be identical to those for the proximal Chromosome (Chr) 7 markers Coh and Xmmv35. This indicates that Zfp30 is within 4.3 cM (at 95% probability) of these two loci . This region of mouse Chr 7 is present on human Chr 19q, suggesting that a human homolog of Zfp30 may map here. It is as yet unclear whether the large number of zinc finger genes present in vertebrate genomes are present mainly as clusters of genes of related function.