Zinc Finger Protein 32 (ZNF32)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.Cannizzaro et al. (1993) mapped the ZNF32 (KOX30) gene by in situ hybridization to chromosome 10q23-q24. The site is near that which, under certain in vitro conditions, demonstrates the development of fragile sites: FRA10D, FRA10A, FRA10B, and FRA10E. Furthermore, deletions in the 10q23-q24 region have been observed in association with malignant lymphoma and carcinoma of the prostate.