Zinc Finger Protein 320 (ZNF320)

ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.Northern blot analysis detected a single, approximately 4.5-kb transcript at highest levels in placenta, pancreas, kidney, and heart and at lower levels in liver, skeletal muscle, and brain. RT-PCR analysis demonstrated expression of ZNF320 in several cancer cell lines tested, including glioblastoma cell line A172. Chernova et al. (2001) determined that the translocation resulted in deletion of exon 5 and fusion of intron 4 of WDR11 to the 3-prime untranslated region of ZNF320. Because of the presence of unrearranged chromosome 19 in the A172 cells, Chernova et al. (2001) could not determine whether the t(10;19) translocation affected the expression of the altered ZNF320 gene.