Zinc Finger Protein 323 (ZNF323)

ZNF323 is a member of the subfamily of C2H2 Kruppel-like zinc finger transcription factors that have a SCAN box domain. The deduced 406-amino acid protein has a predicted molecular mass of 44.66 kD. The protein contains 6 different C2H2 zinc finger domains in tandem arrays in the C terminus, and a highly conserved zinc finger-associated SCAN box, a 95-residue leucine-rich region with 3 predicted alpha-helices, in the N terminus. Northern blot analysis detected a 3.2-kb transcript in most embryonic tissues from 18 to 23 weeks, with highest expression in liver, followed by kidney and lung, and lower expression in intestine, brain, muscle, cholecyst, heart (at 18 weeks only), and pancreas. In adult tissues, ZNF323 was expressed at high levels in liver and kidney, and at lower levels in intestine, brain, heart, and muscle.