Zinc Finger Protein 33B (ZNF33B)

By a combination of in situ chromosomal hybridization and somatic cell hybrid analysis, Rousseau-Merck et al. (1992) concluded that there are sequences hybridizing to the KOX2 probe at 2 loci, which they called ZNF11A (ZNF33A) and ZNF11B (ZNF33B), that map proximal and distal to a 10q11.2 breakpoint, respectively. They suggested that the 2 ZNF11 loci represent related sequences. Tunnacliffe et al. (1993) identified 2 related zinc finger gene clusters mapping to the pericentromeric region of chromosome 10. Cluster A contains ZNF11A (ZNF33A) and ZNF37A and maps to chromosome 10p11.2. Cluster B contains ZNF11B (ZNF33B) and ZNF37B and maps to chromosome 10q11.2. Southern blot analysis indicated that the 2 clusters evolved by duplication of an ancestral gene cluster before the divergence of the human and great ape lineages.