Zinc Finger Protein 36, C3H-Type Like 2 (ZFP36L2)

ZF36L2 gene contains 2 exons. Except for the 3-prime UTR, the entire gene is GC rich. The promoter region contains a GC box, a CAT box, and a CRE element. The 3-prime UTR contains 5 copies of the ATTTA sequence, a characteristic of unstable mRNAs.The deduced 493-amino acid protein has a calculated molecular mass of 51 kD. It contains a zinc finger domain, polyglutamine and polyproline tracts that may act as transcriptional activators, a polyalanine tract, and 3 putative phosphorylation sites. Clusters of serine, proline, alanine, and glycine account for nearly half of the ERF2 sequence. Human ERF2 contains 97 additional amino acids at its C terminus relative to mouse Tis11d, but it shares 90% amino acid identity with mouse Tis11d prior to the C-terminal divergence.