Zinc Finger Protein 367 (ZNF367)

ZNF367 gene contains 5 exons and spans 63 kb.The 320-amino acid human protein shares 71% identity with Zf2, including 93% identity within the zinc finger domains.The deduced proteins contain 306 and 350 amino acids, respectively. Both have an N-terminal proline-rich region and 2 Kruppel-like C2H2 zinc fingers, and ZFF29b has a C-terminal acidic region. Northern blot analysis detected 2.8- and 2.0-kb transcripts in an erythroid cell line, but expression was weak or undetectable in adult tissues. RT-PCR analysis of mouse tissues detected Zff29 expression in fetal liver and adult bone marrow and ovary, with lower levels in other tissues examined. Fluorescent microscopy demonstrated nuclear expression of both ZFF29 isoforms.