Zinc Finger Protein 41 (ZNF41)

Zinc finger domains, loop-like motifs formed by the interaction of 2 invariant pairs of cysteines and histidines with a zinc ion, were first described in transcription factor IIIA in Xenopus oocytes. Franze et al. (1991) isolated a novel human zinc finger gene, ZNF41, from a human X-chromosome-specific library. Nucleotide sequence analysis showed that ZNF41 potentially encodes a polypeptide featuring an array of 18 contiguous zinc fingers of the C2H2 type. Multiple polyadenylated transcripts homologous to ZNF41 are present at different levels in several distinct cell types.Rosati et al. (1999) reported that ZNF41 contains a KRAB/FPB (Kruppel-associated/finger preceding box) domain, a potent transcription repression motif composed of 2 protein modules, A and B.