Zinc Finger Protein 433 (ZNF433)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases. ZNF433, Belongs to the krueppel C2H2-type zinc-finger protein family, May be involved in transcriptional regulation. No SNPs outside the HLA region reached a genome wide level of significance. An association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.